JICDRO is a UGC approved journal (Journal no. 63927)
Year : 2019  |  Volume : 11  |  Issue : 1  |  Page : 3-8

Role of Interleukin-17 in immunopathology of chronic and aggressive periodontitis

1 Department of Periodontology, V.Y.W.S Dental College and Hospital, Amravati, India
2 Department of Periodontology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India

Correspondence Address:
Dr. Anand Narayanrao Wankhede
V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jicdro.jicdro_4_19

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Interleukin-17 (IL-17) is a pro-inflammatory cytokine which is derived from T-cells. It is a strong agent of inflammation in inflammatory condition including the periodontitis. Several studies have focused on finding the role of IL-17 in the initiation and progression of chronic periodontitis and aggressive periodontitis (AgP). The aim of this review is to analyze the role of IL-17 in immunopathology of chronic periodontitis and AgP. An electronic literature search was conducted in the PubMed database using keywords aggressive, chronic, cytokine, IL-17, and periodontitis. A total of 152 publications were identified, wherein 43 studies fulfilled the inclusion criteria which were included and data extraction was done. Findings of these studies indicate that IL-17 is the important cytokine which plays a crucial role in the initiation and progression of periodontitis. More studies in all ethnic groups are necessary and hence that the predictive value (cutoff) of IL-17 levels in chronic and AgP can be determined.

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